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Get Open Targets Graphql Schema

Retrieve the Open Targets Platform GraphQL schema filtered by category. You MUST specify one or more categories to retrieve the relevant schema subset. Categories group related GraphQL types into coherent subschemas (e.g., 'drug-mechanisms', 'genetic-associations', 'target-safety'). The returned schema includes types from the specified categories plus their dependencies expanded. Available categories: - cancer-genomics: Cancer-specific genomic evidence from Cancer Gene Census, IntOGen, canc

Get Type Dependencies

Get schema subsets for types, separated by specific and shared deps. Given a list of type names, returns SDL (Schema Definition Language) organized into type-specific dependencies and shared dependencies. Args: type_names (list[str]): List of GraphQL type names to start exploration from. (examples: ['Target', 'Drug']) Returns: (dict[str, str]): Dictionary with one key per input type: SDL for types ONLY reachable from that type and 'shared' key: SDL for types reachable from multiple in

Search Entities

Search for entities across multiple types using the Open Targets Platform search API. This tool performs a streamlined entity search that returns the id and entity type for up to 3 matching entities across targets, diseases, drugs, variants, and studies. Supports multiple query strings in a single call - each query is executed independently and results are returned in a dictionary keyed by the query string. Args: query_strings (list[str]): List of search queries. (examples: ['BRCA1', 'asp

Query Open Targets Graphql

Execute GraphQL queries against the Open Targets Platform API. WORKFLOW - Follow these steps in order: Step 1: RESOLVE IDENTIFIERS If user provides common names (gene symbols, disease names, drug names), use `search_entity` tool FIRST to convert them to standardized IDs: - Targets/Genes: "BRCA2" -> ENSEMBL ID "ENSG00000139618" - Diseases: "breast cancer" -> EFO/MONDO ID "MONDO_0007254" - Drugs: "aspirin" -> ChEMBL ID "CHEMBL1201583" - Variants: Use "chr_pos_ref_alt" fo

Batch Query Open Targets Graphql

Execute the same GraphQL query multiple times with different variable sets. Use this tool instead of the regular query tool when you need to run the same query repeatedly with different arguments (e.g., querying multiple drugs, targets, or diseases). WORKFLOW - Follow these steps in order: Step 1: RESOLVE IDENTIFIERS If user provides common names (gene symbols, disease names, drug names), use `search_entity` tool FIRST to convert them to standardized IDs: - Targets/Genes: "BRCA1"