Nullary
Nullary
Negative results intelligence for drug discovery. 122M+ measured negative findings across 7 modalities, MCP-installable in 30 seconds. Two technical reports with honest validation: bioactivity prediction at 0.78 ROC-AUC under temporal split, tractability externally validated at AUC 0.78 against independent structural druggability.
https://nullary.aiUse in your AI tool
Use the tools from this page
Opens ChatGPT on the web or desktop and asks it to use the WebMCP tools available here.
Connect the MCP server
Connect straight to this server’s public endpoint.
https://mcp.nullary.ai/mcpUse on MCPBundles
We add this server to your workspace, then open Studio — saved access, one connection to many servers, with a history of what ran.
Last probed Sep 14, 2026 · mcp.nullary.ai
35tools discovered
Tools discovered (35)
Showing 25 of 35 from the live probe.
Search Inactive Compounds
Inactive small-molecule compound-target pairs.
Search Failed Selectivity
Small molecules that failed selectivity.
Search Admet Failures
Small-molecule ADMET failures.
Search Failed Guides
Failed/ineffective CRISPR guides.
Search Failed Essentiality Screens
Non-dependency / failed essentiality screens.
Search Ancestry Specific Failures
Ancestry-specific CRISPR failures.
Search Developability Failures
Antibody developability failures.
Search Failed Clinical Antibodies
Discontinued/terminated clinical antibodies.
Search Failed Peptide Therapeutics
Failed peptide therapeutics.
Search Peptide Stability Issues
Peptide stability/half-life failures.
Search Failed Protacs
PROTACs that failed degradation/ternary/permeability.
Search Protac E3 Issues
PROTAC E3-ligase recruitment / ternary failures.
Search Failed Oligonucleotides
ASOs/siRNAs that failed engagement/developability.
Search Oligo Delivery Failures
Oligonucleotide delivery failures.
Search Failed Vaccines
Failed/terminated vaccines (by pathogen/indication).
Search Vaccine Immunogenicity Failures
Failed vaccine immunogen designs.
Search Failed Adcs
ADCs that failed at any stage.
Search Adc Linker Failures
ADC failures attributed to linker chemistry.
Search Failed Bispecifics
Bispecifics that failed at any stage.
Search Bispecific Format Failures
Bispecific format/engineering failures.
Search Admet Failures All Modalities
ADMET failures across ALL modalities.
Search Drug Drug Interaction Failures
Drug-drug interaction failures.
Search Mechanism Failures
Approaches that failed for a mechanism (by target).
Search Failed Replications
Findings that failed to replicate.
Search Safety Failures
Clinical/preclinical safety failures across modalities.
Get your MCP into directories
A working endpoint is step one. Directory coverage is the coordinated launch across ChatGPT, Claude, Cursor, the MCP Registry, and community indexes.
Directory coverage for brandsFrequently Asked Questions
What is the Nullary MCP server?
Negative results intelligence for drug discovery. 122M+ measured negative findings across 7 modalities, MCP-installable in 30 seconds. Two technical reports with honest validation: bioactivity prediction at 0.78 ROC-AUC under temporal split, tractability externally validated at AUC 0.78 against independent structural druggability.
How do I connect Nullary to my AI agent?
Use the MCP endpoint listed on this page in your MCP client configuration. One-click install pills support Claude, Cursor, VS Code, and other hosts. Copy the remote MCP URL if your client needs a manual entry.
How many tools does Nullary provide?
MCPBundles probed 35 tools on the live server. The tool list on this page reflects what was discovered at the last refresh — connect your client to see the full set available to your session.
What authentication does Nullary require?
No provider sign-in was required during MCPBundles' probe. Your client may still need MCPBundles credentials depending on how you connect.
Maintain this listing
Operate Nullary? Verify ownership to take over this directory entry.
Operate Nullary?
This server appears in the MCPBundles directory. Verify you operate it to take over the listing — name, description, logo, contact email, and skill content. We email a 6-digit code to a maintainer address your server publishes in /.well-known/security.txt or /.well-known/mcpbundles.json. Free, takes about a minute.
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